Dr. Cheng Luo's Logbook

Dr. Cheng Luo, Bachelor of Sichuan University (1982), Doctor of Virology (1993), University of Helsinki, Finland, worked in Wuhan Institute of Virology, Chinese Academy of Sciences (1982-1988), University of Vienna (1989-1990), University of Helsinki (1990-1993) , French Academy of Agricultural Sciences (INRA, 1994-1995), University of Umea, Sweden (1996-1998), University of Turku, Finland (1998-2003), OMRF, Oklahoma, USA (2003-2004), University of Hong Kong (2005-2007), Tartu University, Estonia (2008-2013). Distinguished professor of Tianjin University of Science and Technology (2010-2014), Distinguished (2nd rank) professor of Zhejiang Ocean University (2016-2020). Retire in 2022. At present, he mainly assists in the review of several (basic) medical journals. 罗成，四川大学学士（1982），病毒学博士（1993），芬兰赫尔辛基大学，先后在中国科学院武汉病毒研究所（1982-1988）、维也纳大学（1989-1990）工作， 赫尔辛基大学（1990-1993），法国农业科学院（INRA，1994-1995），瑞典于默奥大学（1996-1998），芬兰图尔库大学（1998-2003），OMRF，Oklahoma，USA（ 2003-2004，香港大学（2005-2007），爱莎在尼亚塔图大学工作（2008-

  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832118/ 大鼠运动后的机械痛觉过敏需要通过肌肉中环氧合酶 2 激活上调神经胶质细胞系衍生的神经营养因子 In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons, and, in some instances, it has also been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine fashion by forming a complex with the GDNF family receptor α1 (GFRα1), which is mainly expressed by neurons and can act in cis as a membrane-bound factor or in trans as a soluble factor. The GDNF/GFRα1 complex signals through interactions with the “rearranged during transfection” (RET) receptor or via the neural cell adhesion molecule (NCAM) with a lower affinity. GDNF can also signal independently from GFRα1 by interacting with syndecan-3. RET, which is expressed by neurons involved in several pathways (nigro–striatal dopaminergic neurons, motor neurons, enteric neurons, sensory neurons, etc.), could be the main determinant of the specificity of