Dr. Cheng Luo's Pensioner Working Page
A Chinese/Finnish scientist, Sichuan University (1978-1982, Chengdu, China), resaech assistant in baceriophages (Vienna University,1988-1989), virus structure (Helsinki U 1989-1993), plant physiology (Umeå U 1996-1998), medicine (Turku U 1998-2003) COX-2 in pancreatic beta-cells. Recipient for traveling support to Hawaii, USA for COX-2 (inhibitor) workshop, Pfizer, 1999, Wang K. Edu. Foundation, Hong Kong, China, 2000. OMRF, USA 2003-04, HKU 2005-2007, Biotechnology: Senior Scientist Tartu U. 2008-2015, Food Sci. Professor Tianjin U 2010-2014, Zhejiang Ocean U 2016-2020.
Current interests:
1, GDNF gene network to artificial neural network
Some thoughts or ideas ongoing
I studied PTGS2 (COX-2) for more than 15-20 years, an enzyme constitutively** expressed in neuron of cerebral cortex (especially motor cortex), the neurology, or neurologist believe COX-2 and its downstream product, the prostaglandins activate or provide the physiological metabolism for an excitatory neuron that conduct nerve impulse, or fire action potentials beside possible pathological roles. At present, PTGS2 is widely believed to be involved, or participated, or trigger many cerebral diseases including brain tumor, Parkinson disease and Alzheimer diseases, etc. because of their inflammatory roles
On the other hand, GDNF (Glial cell line-derived neurotrophic factor) is expressed in glial cells, promote glial cell proliferation, provides physical and metabolic support to neurons, but act as inhibitory to neuron. At present GDNF is widely believed to reduce, or even cure cerebral diseases, such so called GDNF therapy has helped to PD or AD in some scales, but not to the cerebral tumors.
Both genes are regarded as hub genes even though they do not directly interact, but each trigger a chain reaction, they do coordinate each other for brain function. Further understanding 2 genes interaction may help the cerebral diseases, more may help to construct the artificial neuron network whether through bionic approach or hierarchy approach, or data mining (neural networks are the result of data mining).
There are some algorithms, or models, or methods of
mining, such as recurrent neural network (RNN) …. However, just wonder someone
may be interested in PTGS2/GDNF gene/neuron (artificial) network? Of course,
the first question is:
Is possible to construct a PTGS/GDNF (backborne)
gene/neuron (artificial) network?
Cheng Luo (Luo58@yahoo.com)
** PTGS2 is exceptionally constitutively expressed in cortex, widely regarded PTGS2 as inductive isoform, where PTGS1 as constitutive isoform.
GDNF (Glial cell line-derived neurotrophic factor), a member of the transforming growth factor-beta superfamily, was first identified from glial cells and has the ability to protect midbrain dopaminergic neurons (Engele et al.). ., 1991; Lin et al., 1993), GDNF also applies to the ENS (enteric nervous system). Overexpression or abnormal expression of GDNF is currently known to cause brain tumors, Hirschsprung's disease, especially with neurocognitive function (schizophrenia) and habituation tendencies, such as GDNF has been identified as a potential common addiction-related gene ( For example, drug, alcohol, etc.). This may be because GDNF is expressed in the brain and other neuronal cells.
The main idea is to make a model, or through some ready-made models, to quickly transform the GDNF, or GDNF/PTGS2 gene network into the currently widely recognized neural network, which can be further developed into psychiatry by analyzing certain target genes from individual blood samples. or other clinical applications (APP).
RNN: Recurrent Neural Networks (RNNs) are a class of neural networks that help model sequence data. RNNs are derived from feedforward networks and exhibit behavior similar to how the human brain functions. In short: Recurrent Neural Networks produce predictions in sequential data that other algorithms cannot.
CNN: is a "feedforward neural network" that uses filter and pooling layers, while RNN feeds the results back into the network. In CNN, the size of the input and the resulting output are fixed.
Transformer: Models have been one of the main highlights of the advancement of deep learning and deep neural networks. Transformer neural networks are acyclic models for processing sequential data such as text.
Build neural networks in Python using packages like Keras and TensorFlow.
https://genemania.org/search/homo-sapiens/gdnf/ptgs2
2, Near-Infrared Database System for food safety in real time analysis: The food safety was a big problem in the beginning of 2000, typically melamine in milk powder was caught in media worldwide. And we learn that the NIR spectrometer is becoming smaller and smaller thanks to the linear variable filter (LVF) as modern spectroscopic element replacing the traditional prism, which make it possible to produce pocketable NIR spectrometer. And 5G telecommunication make is possible to do food safety check in real time because the spectra can be locally and remotely analyzed against different molecule database.
09.07.2022 Oodi library (group room 3), Helsinki, Finland
Dr. Cheng Luo's CV
First name: Cheng, Surname: Luo
Permanent Address: Helsinki, Finland
Email:
Luo58@yahoo.com
Born: Oct. 26, 1958 in Guizhou, China,
Gender: male. Citizenship: Finland (hold passport of Finland since June 1998)
Language: English and Chinese, some Finnish
and Swedish.
Main Education
1990-1994 Ph. D. University of Helsinki, Department of Genetics, Finland
1978-1982 Sichuan University, Microbiology, China. B.S.
Main interests: Food Science
Main
subjects of education: Advanced mathematics,
inorganic chemistry, organic chemistry, advanced physics, biology,
microbiology, genetics, molecular immunology, molecular genetics, biochemistry,
biophysics, virology, molecular cancer biology, cell biology, molecular
biology, basic botany and zoology, Electronic microscopy, etc..
Employment:
01/2016 -
2020 Zhejiang Ocean University, Food Science,
Professor
01/2010 -12/ 2014 Visiting Professor (Molecular and cell biology, Food science) Tianjin University of Science and Technology, China. Supervised 13 Master students.
03/2008- 12/ 2013 Senior Scientisit (Bioinformatics and ageing study) Institute of Molecular and Cell Biology, University of Tartu, Estonia. Co-supervised 1 Ph. D student.
01/ 2007- 01/ 2008 Visiting Professor (pharmacognosy), Kunming Institute of Botany, Chinese Academy of Science, China.
01/2005 –12/2006 Research Scientist (Cancer Biology) Institute of Biotechnology, The University of Hong Kong
09/ 2003 –10/ 2004 Associate Research Scientist (HIV immunology), Lipid rafts in T-cell activation. Oklahoma Medical Research Foundation, OK, USA
07/1998- 08/ 2003 Scientific Researcher (hormone related cancer studies, diabetes), COX-2’s roles in cancer and diabetes. University of Turku, Finland.
01/1996 - 06/1998 postdoc. (plants AGPase), Dept. of Plant Physiology, Umeå University, Umeå, Sweden.
12/1994 - 12/1995 postdoc. Dijon, INRA, Laboratory of Soil Microbiology, France
12/1990-11/1994 Ph. D student (E. coli virus), Dept of Genetics, University of Helsinki, Finland
11/1989 -11/1990 Research assistant (Bacteriophage) Institute of Microbiology and Genetics, University of Vienna, Austria
08/1982-10/1989 Wuhan Institute of Virology, Chinese Academy of Science, Wuhan, China
Publication: https://orcid.org/0000-0001-7214-9195；https://www.researchgate.net/profile/Cheng_Luo3，
Zhenjing Li1, 2, Yibin Xue1, 2, Mengxian
Li1, 2, Qingbin Guo1, 2, Yaxin Sang3, Changlu Wang1, 2, and Cheng Luo1, 2＊ The Antioxidation of Different
Fractions of Dill
(Anethum graveolens) and Their Influences
on Cytokines in Macrophages RAW264.7，J. Oleo Sci. 67, (12) 1535-1541 (2018)
Zhenjing Li,1,2 Xiaohong， Zhang,1,3 Yibin Xue,1,2 Jingkai Zhang,1
Meiling Li,1
and Cheng Luo 1, Cellular and Molecular
Evidence of Acetaldehyde Elimination and
Intracellular Environment Antioxidation by
L-Cysteine， Hindawi Journal
of Chemistry
Volume 2018, Article ID 6864574, 8 pages
1, Deng, Shanggui, Lutema, Phares, Gwekwe,
Blessing, Li, Yingjie, Akida, Jamal, Pang, Zan, Huang, Youkun, Dang, Yali,
Wang, Shuqi, Chen, Meiling, Miao, Wenhua, Lin, Huimin, Wang, Likui, Luo, Cheng,
2019/11/01, Bitter peptides increase engulf of phagocytes in vitro and inhibit
oxidation of myofibrillar protein in peeled shrimp (Litopenaeus vannamei)
during chilled storage. Aquaculture Reports Volume 15, November 2019, 100234 Doi:
10.1016/j.aqrep.2019.100234 IF=2.6
2， Cheng Luo, Blessing Gwekwe, Phares Choto,
Wenhua Miao, Meiling Chen, Changfeng Xue, Yunsheng Xu, Xiaolong Yin, Glory
Magawa，Di Wu, Jamal S. Akida, Likui Wang,
Qingqing Li, Shanggui Deng Bitter peptides from enzymatically hydrolyzed
protein increase the number of leucocytes and lysozyme activity of large yellow
croaker (Larimichthys polyactis), Fish Shellfish Immunol. 2018 Oct;81:130-134.
doi: 10.1016/j.fsi.2018.07.013. Epub 2018 Jul 10. IF=3.9
3, Luo
C, Wu D, Magawa G, Omodo J, Xue C, Sun Y, Liu D, Xie C, Wang Y, Frenz C, Deng
S. Inhibition of migration and invasion of hepatocarcinoma HepG2 cells by
dietary saponins via targeting HIF-1α. Anticancer Agents Med Chem. 2018 Jan 10. IF= 2.9
|
4, Luo C, Wang X, An C, Hwang CF, Miao W,
Yang L, Xu M, Bai A, Deng S. Molecular inhibition mechanisms of cell
migration and invasion by coix polysaccharides in A549 NSCLC cells via
targeting S100A4. Mol Med Rep.
2017 Jan;15(1):309-316. IF=1.9 5,
Chin-Fa Hwang, Yi-An Chen, Chen Luo &
Wen-Dee Chiang, Antioxidant and antibacterial activities of peptide fractions from flaxseed protein
hydrolyzed by Bacillus altitudinis HK02, International J of
Food Science and Technology, 2016,
IF=1.5 51(3) :681-689. 6， Cheng Luo and Shanggui Deng，Viili as Fermented Food in
Health and Disease Prevention: A Review Study，Journal of Agricultural Science and Food
Technology，Vol.2 (7), pp. 105-113,2016。 7， Cheng Luo, Xin Wang, Can An, Chin-fa
Hwang, Wenhua Miao, Lu Yang, Maonian Xu,
Aiping Bai, Shanggui Deng, Molecular inhibition mechanism of cell migration and
invasion by coix polysaccharides in NSCLC A549 cells via targeting
S100A4, MMR, Vol 15， No.1， 2017. DOI: 10.3892/mmr.2016.5985 IF=3.5 8, Shi L, Yuzhen Pi, Cheng Luo, Chunhong
Zhang, Dehong Tan, Xianjun Meng, In vitro
inhibitory activities of six gypenosides on human liver cancer cell
line HepG2 and possible role of HIF-1a pathway in them, Chemico-Biological
Interactions 238 (2015) 48–54 IF=3.3 9, Likui Wang, Yuefang Xu, Cheng Luo, Jian
Sun, Jinlu Zhang, Ming-Wei Lee, Aiping Bai,
Guanhua Chen4, Christopher M. Frenz, Wenlin Huang, MAGEA10
gene expression in non small cell lung cancer and A549 cells, and the
affinity of epitopes with the complex of HLA-A*0201 alleles，Cellular
Immunology, 2015 (1.9)  10, Fei Hou, likui wang, hong wang, junchao gu, meiling
li, jingkai zhang, xiao ling, xiaofang gao and Cheng Luo, Elevated gene expression of S100A12 is correlated
with the predominant clinical inflammatory factors in patients with bacterial
pneumonia, MMR., 11: 4345-4352, 2015，DOI: 10.3892/mmr.2015.329，
2015 SCI = 1.17 |
|
|
11, Likui Wang, Shijuan Gao, Wei
Jiang, Cheng Luo, Maonian Xu, Lars Bohlin, Markus Rosendahl and Wenlin
Huang, Antioxidative Dietary
Compounds Modulate Gene Expression Associated with Apoptosis, DNA Repair,
Inhibition of Cell Proliferation and Migration. Int. J. Mol. Sci. 2014,
15, 16226-16245; doi:10.3390/ijms150916226 SCI
= 2.598 (3区) |
|
12, Wei Liu , Xiangyi Lu , Guangyang He , Xiang
Gao, Maonian Xu, Jingkai Zhang, Meiling Li, Lifeng Wang, Zhenjing Li, Likui
Wang, Cheng Luo*， Protective Roles of Gadd45 and MDM
13, Junhua Wu, Mengxian Li, Ling Liu, Qi An,
Jinlu Zhang, Jingkai Zhang, Meiling Li, Weigang Duan, Dequan Liu, Zhenjing Li,
Cheng Luo*. Nitric Oxide and Interleukins are Involved in Cell Proliferation of
RAW264.7 Macrophages Activated by Viili Exopolysacchrides. Inflammation, 2013,
Vol 36, No. 4, pp 954-961. http://www.ncbi.nlm.nih.gov/pubmed/23515856 SCI = 2.457 (3区)
14， Lu X, Liu W, Wu J, Li M, Wang J, Wu J, Luo
C*. A polysaccharide fraction of adlay seed (Coix lachryma-jobi L.) induces
apoptosis in human non-small cell lung cancer A549 cells. Biochem Biophys Res
Commun. 2013, vol. 430 (2): 846-851.
doi: 10.1016/j.bbrc. 2012. 11.058.
SCI = 2.542(3区)
15, Liu W, Lu X, He G, Gao X, Li M, Wu J, Li Z, Wu
J, Wang J, Luo C*. Cytosolic protection against ultraviolet induced DNA damage
by blueberry anthocyanins and anthocyanidins in hepatocarcinoma HepG2 cells.
Biotechnol Lett. 2012 Nov 29. https://www.ncbi.nlm.nih.gov/pubmed/23192380
SCI = 1.853
16, Gao X, Liu Q，Zhao
Y, Li Z, Zhou, Jiang K, Luo C*. 2012 Influences of gold and silver nanoparticles in
loop-mediated isothermal amplification (LAMP) reactions, Journal of
Experimental nanosciences DOI:10.1080/17458080.2012.743684， 2012. 743684 CI=1.01
17, Ling Liu, Jingkai Zhang,
Meiling Li, Xiaohong Zhang, Jinlu Zhang, Zhenjing Li, Likui Wang, Jihui Wu,
Cheng Luo*, Inhibition of HepG2 cell proliferation by ursolic acid and
polysaccharides via the downregulation of cyclooxygenase-2. Mol Med
Rep. 2014 Mar 17. doi: 10.3892/mmr.2014.2059. [Epub ahead of print] SCI=1.170
18, Wang C, Yang H, Chen M, Wang Y, Li F, Luo C, Zhao S,
He D. Real-time quantitative analysis of the influence of blue light on
citrinin biosynthetic gene cluster expression in Monascus. Biotechnol Lett. 2012
Sep;34(9):1745-1748 SCI =
1.853
19， Liu L. Wu JH. Zhang JL,
Li ZJ，Wang CL, Chen MH, Wang
YR, Sun YX, Wang LK, Luo C*.A compatibility assay of
ursolic acid and foodborne microbial exopolysaccharides by antioxidant power
and anti-proliferative properties in hepatocarcinoma cells. J. Food, Agriculture, Environment 2012, 10 (2):
111-114. SCI=0.517
20, Kan Jiang*, Qinfeng Lv, Donglei Zhang, Xiang
Gao , Yi Zhao, Mengxian Li, Ling Liu, Junhua Wu, Xiangyi Lu and Cheng Luo*，A novel, sensitive,
accurate multiplex loop-mediated isothermal amplification method for detection
of Salmonella spp., Shigella spp. and Staphylococcus aureus in food. JFAE,
2012, Vol. 10, No. 3-4, pp252-256， SCI=0.571
21, Yi Zhao, Jingkai
Zhang, Meiling Li, Zhenjing Li, Xiang Gao, Cheng Luo*, A duplex loop-mediated isothermal
amplification method for the simultaneous detection of Escherichia coli and
Vibrio parahaemolyticus in food, IJFAE, 2013, vol, No. 3, SCI = 0.571
22, Tingtao
Chen , Qianglai Tan, Mengjuan Wang, Shunqiang Xiong, Shuying Jiang, Qinglong
Wu,
Shengjie Li, Cheng Luo* and Hua Wei, Identification of bacterial strains in
viili by molecular taxonomy and their synergistic effects on milk curd and
exopolysaccharides production, African J. of
Biotechnology, 2011, Vol. 10(74), pp. 16969-16975, SCI = 0.521
23， Wang C, Yang H, Chen M, Wang Y, Li F, Luo C, Zhao S, He
D.Real-time quantitative analysis of the influence of blue light on
citrinin biosynthetic gene cluster expression in Monascus. Biotechnol Lett. 2012
34(9):1745-1748. doi: 10.1007/s10529-012-0962-z. SCI=1.853
24， Luo, C.*; Urgard, E.; Vooder, T.; Metspalu, A. (2011). The role of
COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and
anti-aging. Medical Hypotheses, 77(2), 174 - 178 . SCI
= 1.054
25． Urgard, Egon; Vooder, Tõnu; Võsa, Urmo; Välk, Kristjan; Liu, Mingming;
Luo, Cheng; Hoti, Fabian; Roosipuu, Retlav; Annilo, Tarmo; Laine, Jukka; .
Frenz, Christopher M; Zhang, Liqing; Metspalu, Andres (2011). Metagenes
associated with survival in NSCLC. Cancer Informatics, 10, 175 - 183.
26. Sun WH, Chen GS, Ou XL, Yang Ye, Luo C, Zhang Y,
Shao Y, Xu HC, Xiao B, Xue YP,
Zhou SM, Zhao QS, Ding GX, 2009 Inhibition of cyclooxygenase-2 and
activation of peroxisome proliferator-activated receptor-γ synergistically
inhibits proliferation and induces apoptosis of human pancreatic carcinoma
cells. 275,247-255. SCI = 4.258
27， Sun WH, Su
H,Zhu F, Chen GS, Luo C, Zhao Q, Zhang Y. Shao Y, Sun J, Zhou SM, Ding GX, Cheng YL, 2008, Blockade of
cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell
apoptosis, but independently inhibits the proliferation of human gastric cancer
cells in vitro, Cancer Letter, Vol. 263, p. 302-311. SCI = 4.258
28， Luo C*, Wang
K, Liu DQ, Li Y, Zhao Q, The Functional Roles of Lipid Rafts in T-Cell
Activation, Immune Diseases and HIV Infection and Prevention. Cell and
Immunology, Vol.5 No.1, p.1-7, 2008. SCI = 4.110
29， Luo C*, Peng
Y, Santti R, He ML and Lin MC. COX-1 and
2 expressions in sex-related organs of neonatally estrogen treated rats and in
activated and non-activated macrophage RAW264.7cells with phytoestrogen,
Endorine,Vol.29, No.1, p.161-167,2006. SCI = 2.250
30， Luo C*, He
ML and Bohlin L. 2005, Is COX
31， Luo C*,
Simell O, Kung HF and He ML, The simultaneous and spontaneous coexpression of
insulin and COX
32， Luo C* and
Laaja P, 2004, Inhibitors of JAKs/STATs and the kinases, a possible new cluster
of drugs, Drug Discovery Today, Vol.9, No.6, pp268-275. SCI = 6.511, (2区)
33，. Luo C*,
Kallajoki M, Makinen M, Teros T, Ylinen L, Simell O, 2002, Distribution and
contribution of cyclooxygenase(COX)-2 for diabetogenesis in NOD mouse model,
Cell &Tissue Research,Vol.310, p169-175. SCI =
3.677
34， Luo C*,
Laine JVO, Ylinen L, Teros T, Makinen M, Ristimaki A, and Simell O, 2002,
Expression of cyclooxygenase
35，Luo C*,
Strauss L, Streng T, Ristimaki A ,Santti R. Constant Expression of
cyclooxygenase-2 gene in the lower urinary tract and prostate of the mail rats
treated with estrogen, Zeitschriftfur Naturforschung,
36，Wu.X,
Sallinen K, Antila L, Makinen M, Luo C, Pallanen P, Erkkola R. 2000, Expression
of insulin-receptor substrate-1 and
37，Weigang Duan, Wenhui Chen, Yu Yun, Dequan
Liu, Cheng Luo, Zhiqiang
Shen, Serum-Free Medium
Evokes Cyclooxygenase2 Pathway in A549 Cells. The Open Inflammation Journal -
OPEN INFLAMM J 01/2009; 2(1):34-37. DOI:10.2174/1875041900902010034
38, Luo, C.; Kleczkowski,
L.A. (1999). Expression of barley ADP-glucose
pyrophosphorylase in Escherichia coli:
Processing and regulatory considerations . Phytochemistry, 50(2), 209 -
214. SCI =
3.750
39, Kleczkowski, L.A.; Sokolov, L.N.; Luo, C.;
Villand, P. (1999). Molecular cloning and spatial expression of an
ApL1 cDNA for the large subunit of ADP-glucose pyrophosphorylase from
Arabidopsis thaliana. Zeitschrift Fur Naturforschung C-a Journal of
Biosciences, 54(5-6), 353 - 358. SCI = 0.621
40, Witte, A.; Baranyi, U.; Klein, R.; Sulzner,
M.; Luo, C.; Wanner, G.; Kruger, D.H.;
Lubitz, W. (1997). Characterization of Natronobacterium magadii phage Phi Ch1,
a unique archaeal phage containing DNA and RNA. Molecular Microbiology, 23(3),
603 - 616. SCI = 4.961
41, Eimert, K.; Luo, C.; Dejardin, A.; Villand,
P.; Thorbjornsen, T.; Kleczkowski, L.A.
(1997). Molecular cloning and expression of the large subunit of ADP-glucose
pyrosphosphorylase
from barley (Hordeum vulgare) leaves. Gene,
189(1), 79 - 82. SCI = 2.196
42, Luo, C.; Dejardin, A.; Villand, P.; Doan, D.;
Kleczkowski, L.A. (1997). Differential processing of
homologues of the small subunit of ADP-glucose pyrphosphorylase from
barley(Hordeum vulgare) tissues. Zeitschrift Fur Naturforschung C-a Journal of
Biosciences, 52(11-12), 807 - 811. SCI = 0.621
43, Hantula, J.; Koivula, T. T.; Luo, C.;
Bamford, D. H. (1996). Bacterial diversity at surface water in three
locations within the Baltic sea as revealed by culture-dependent molecular
techniques. Journal of Basic Microbiology, 36(3), 163 - 176. SCI = 1.198
44, Bamford, J.K.H.; Luo, C.; Juuti, J.T.;
Olkkonen, V.M.; Bamford, D.H. (1993). Topology of
the major
capsid protein P3 of bacteriophage PRD1: Analysis using monoclonal antibodies
and C-terminally truncated proteins. Virology, 197(2), 652 - 658. SCI = 3.367
45, Caldentey, J.; Luo, C.; Bamford, D.H. (1993).
Dissociation of the lipid- containing bacteriophage PRD1, effects of heat, pH,
and sodium dedecyl sulphate. Virology, 194(2), 557 - 563. SCI = 3.367
46, Luo, C.; Hantula, J.; Tichelaar, W.; Bamford,
D.H. (1993). Bacteriophage PRD1 protein: crosslinking and scanning transmission
electron microscopy analysis. Virology, 194(2), 570 - 575. SCI = 3.367
47, Luo, C.; Butcher, S.; Bamford, DH. (1993).
Isolation of a phospholipid-free protein shell of bacteriophage PRD1, an E.coli
virus with an internal membrane. Virology, 194(2), 564 - 569. SCI = 3.367
Comments
Post a Comment